We are part of the Institute for Biochemistry, Genetics and Microbiology and member of the Regensburg Center for Biochemistry (RCB) at the University of Regensburg.
The Längst Group investigates the mechanisms and dynamics of packaging the eukaryotic and viral genetic material into chromatin and the latter's function in disease processes.
This research includes human chromatin, the genetic packaging of Adenovirus and Coronavirus, and chromatin structure dynamics in the Malaria-causing parasite Plasmodium falciparum.
While our fundamental research focuses on chromatin remodelling complexes and non-coding RNAs in nuclear architecture, nucleosome positioning and gene regulation, our applied research relates to inhibiting the dynamics and packaging of the genetic material to identify new drug targets and block cancer, pathogen and viral growth.
Wernig-Zorc, S. et al.; Sci. Adv. 10, (2024); pmid: 38959309
nucMACC: An MNase-seq pipeline to identify structurally altered nucleosomes in the genome.
We present the nucleosome-based MNase accessibility (nucMACC) pipeline unveiling the regulatory chromatin landscape by measuring nucleosome accessibility and stability. The nucMACC pipeline represents a systematic and genome-wide approach for detecting unstable (“fragile”) nucleosomes.
We have characterized the regulatory nucleosome landscape in Drosophila melanogaster, Saccharomyces cerevisiae, and mammals.
Two functionally distinct sets of promoters were identified, one associated with an unstable nucleosome and the other being nucleosome depleted. We show that unstable nucleosomes present intermediate states of nucleosome remodeling, preparing inducible genes for transcriptional activation in response to stimuli or stress. The presence of unstable nucleosomes correlates with RNA polymerase II proximal pausing.
The nucMACC pipeline offers unparalleled precision and depth in nucleosome research and is a valuable tool for future nucleosome studies.
We are organising basic and advanced teaching activities. Lectures, seminars, and practical courses are offered for medical students, BSc and MSc students in biology, biochemistry, and molecular medicine.
Gernot Längst is the managing director of the International Graduate School Regensburg (RIGeL). All PhD students of the Faculty NWFIII are members of RIGeL.
Our lab hosts a Biophysics Facility to characterize and quantify all kinds of molecular interactions. The facility is accessible to all UR groups.
The Bioinformatic Core Service (GACT) is associated with our group. It is supporting our faculty with advanced bioinformatics regarding high-throughput sequencing analysis.
We are developing Software tools to analyze chromatin structure and to predict sequence specific formation of RNA-DNA triple helices.
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