My research focuses on the cell nucleus, particularly the regulatory role of genome organisation, its influence on gene networks, and the maintenance and inheritance of activity states without alteration of the DNA sequence. This inheritance type— epigenetics — is a central process in organismal development and formation of distinct cell types.
Integrating biochemistry, biophysics, cell biology, and bioinformatics, we investigate the molecular mechanisms of epigenetics. Our team was the first to demonstrate that DNA packaging proteins actively move along DNA. This discovery shed light on the mechanisms behind this remodelling process and showed that the specific positioning of these packaging units on DNA directly affects gene expression.
Currently, the lab is exploring the roles of RNA and non-canonical DNA structures in DNA packaging and their impacts on epigenetic regulation. Recent work focuses on screening for epigenetic drugs to develop treatments for ageing and malaria.
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